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Might bring about intense hypotension including orthostatic hypotension and syncope in ambulatory clients; There may be improved chance in sufferers whose potential to maintain blood pressure has presently been compromised by a lessened blood volume or concurrent administration of sure CNS depressant medicine (e.
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givosiran will enhance the level or result of codeine by influencing hepatic enzyme CYP2D6 metabolism. Stay away from or Use Alternate Drug. Steer clear of coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, reduce the CYP2D6 substrate dosage in accordance with permitted product labeling.
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Acetaminophen Comp. may be taken with or with out food. For motion sickness, a dose is usually taken thirty minutes before movement, then with meals and at bedtime for the period of publicity.
Therapy in individuals with acute or intense bronchial asthma within an unmonitored setting or in absence of resuscitative gear is contraindicated
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Gli oppioidi agiscono legandosi agli specifici recettori (recettori degli oppioidi), che si trovano principalmente nel sistema nervoso centrale e periferico e nel tratto gastrointestinale.